Selected Publications:
Note: Over 60 meeting abstracts presented at different national and international meetings are not included in the list below.
S Varghese. Matrix metalloproteinases and their inhibitors in bone: an overview of regulation and functions. Front Biosci 11, 2949-2966, 2006.
S Varghese, S Rudziel and E Canalis. Bone morphogenetic protein-2 suppresses collagenase-3 promoter activity in osteoblasts through a runt domain factor 2 binding site (J Cell Physiol, 202: 391-399, 2005).
N Wyzga, S Varghese, S Wikel, E Canalis and FA Sylvester. Effects of activated T cells on osteoclastogenesis depend on the method of activation and interferon-g production (Bone, 35:614-620, 2004).
S Varghese and L Liang.Thymosinb4: a highly conserved and regulated multifunctional peptide, elevated in tumor cells (Recent Res Devel Cancer, 6: 317-326, 2004).
S Varghese and E Canalis.Transcriptional regulation of collagenase-3 by interleukin-1 alpha in osteoblasts.J Cell Biochem 90: 1007-1014, 2003.
S Varghese, N Wyzga and F Sylvester.Direct effects of serum from children with Crohn’s disease on bone formation.J PediatrGastroenterolNutr35: 641-648, 2002.
S Varghese.Collagenase in skeletal remodeling.Recent Res DevelEndocrinol 1: 165-176, 2000
S Varghese and E Canalis. Alendronate stimulates collagenase-3 expression in osteoblasts by post-transcriptional mechanisms. J Bone Miner Res 15: 2345-2351, 2000.
S Varghese, S Rydziel and E Canalis. Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1 binding site. Endocrinology 141: 2185-2191, 2000.
S Varghese, K Yu and E Canalis. Leukemia inhibitory factor and oncostatin M stimulate collagenase-3 expression in osteoblasts. Am J Physiol ,276: E465-E471, 1999.
J Xu, DS Cissel, S Varghese, DL Whipkey, JD Blaha, GM Graeber and PE Keeting. Cytokine regulation of adult human osteoblast-like cell prostaglandin biosynthesis.J Cell Biochem, 64: 618-631, 1997.
S Varghese and E Canalis.Regulation of interstitial collagenase by bone morphogenetic protein-2 in bone cell cultures.Endocrinology, 138: 1035-1040, 1997.
S Rydziel, S Varghese and E Canalis. Transforming growth factor b1 inhibits collagenase 3 expression by transcriptional and post-transcriptional mechanisms in osteoblast cultures. J Cell Physiol, 170: 145-152, 1997.
S Varghese, AM Delany, L Liang, B Gabbitas, JJ Jeffrey and E Canalis. Transcriptional and post-transcriptional regulation of interstitial collagenase synthesis by platelet-derived growth factor BB in bone cell cultures.Endocrinology 137: 431-437, 1996.
S Varghese, ML Ramsby, JJ Jeffrey and E Canalis. Basic fibroblast growth factor stimulates expression of interstitial collagenase and inhibitors of metalloproteinases in rat bone cells. Endocrinology 136: 2156-2162, 1995.
E Canalis, S Rydziel, AM Delany, S Varghese and JJ Jeffrey. Insulin-like growth factors inhibit interstitial collagenase synthesis in bone cell cultures. Endocrinology 136: 1348-1354, 1995.
S Varghese, S Rydziel, J Jeffrey and E Canalis.Regulation of interstitial collagenase expression and collagen degradation by retinoic acid in bone cells.Endocrinology 134: 2438-2444, 1994.
E Canalis, J Pash, B Gabbitas, S Rydziel and S Varghese. Growth factors regulate the synthesis of insulin-like growth factor-I in bone cell cultures. Endocrinology 133: 33-38, 1993.
E Canalis, J Pash and S Varghese.Skeletal growth factors.Crit Rev Euk Gene Exp 3: 155-166,1993.
E Canalis, S Varghese, TL McCarthy and M Centrella. Role of platelet derived growth factor in bone cell function. Growth Regulation, 2: 151-155, 1992.
S Varghese and HM Kronenberg. Rat thymosinb4 gene: Intron-containing gene and multiple retroposons. J BiolChem 266:14256-14261, 1991.
S Varghese, LL Deaven , YC Huang, RK Gill, AM Iacopino and S Christakos. Transcriptional regulation and chromosomal assignment of the mammalian calbindin D28k gene.MolEndocrinol 3:495-502, 1989.
TL Wood, Y Kobayashi, G Frantz, S Varghese, S Christakos and AJ Tobin. Molecular cloning of mammalian 28,000 Mr vitamin D-dependent calcium binding protein (calbindin D28k): Expression of calbindin D28k RNAs in rodent brains and kidney. DNA 7:585-593, 1988.
S Varghese, S Lee, YC Huang and S Christakos.Analysis of rat calbindin D28k gene expression.J BiolChem 263:9776-9784, 1988.
S Christakos, T Wood, S Varghese and AJ Tobin. Molecular cloning and regulation of the mammalian 28,000 Mr vitamin D-dependent calcium binding protein (calbindin D28k). In: Norman AW, Vanamen TL, Means A. (eds.) Calcium-binding proteins in health and disease, Academic Press, Inc., New York. 276-284, 1987.
S Varghese and S Christakos. A quantitative immunobinding assay for vitamin D-dependent calcium binding protein (calbindin D28k) using nitrocellulose filters. Anal Biochem 165:183-189, 1987.
GA Skowronski, S Varghese, SB Gertner and SI Sherr. Lung lipoprotein lipase: Inhibition by barbiturates. Pharmacol Res Commun 15:661-673, 1983.
EB Cunningham, S Varghese, S Lee, R Brissette and NI Swislocki.Modulation of the activity of the (Ca2+ + Mg2+)-dependent adenosine triphosphatase of the human erythrocyte.BiochemBiophysActa 731:378-383, 1983.
S Varghese and EB Cunningham. The influence of adenosine 3’5′-monophosphate upon the activity of membrane associated (Ca2+ + Mg2+)-dependent adenosine triphosphatase of the human erythrocyte. BiochemBiophysActa 596:468-471, 1980.